C. Bond

Super-Resolution Imaging Uncovers Nanoscale Tau Aggregate Hyperphosphorylation Patterns in Human Alzheimers Disease Brain Tissue

The paper uses super-resolution imaging to analyze nanoscale tau aggregates in AD and PART brain tissues, revealing hyperphosphorylation patterns and morphological differences.

Multiplexed DNA-PAINT Imaging of the Heterogeneity of Late Endosome/Lysosome Protein Composition

This study uses multiplexed DNA-PAINT imaging to reveal cell-type specific subpopulations of late endosomes/lysosomes with unique protein compositions.

ECLiPSE: A Versatile Classification Technique for Structural and Morphological Analysis of Super-Resolution Microscopy Data

ECLiPSE is a machine learning pipeline for classifying super-resolution microscopy data, achieving high accuracy in identifying cellular structures and applying to tau protein clearance and TDP-43 morphotypes.

Detyrosination enrichment on microtubule subsets is established by the interplay between a stochastically-acting enzyme and microtubule stability

The paper investigates how detyrosination of microtubules occurs on specific subsets through stochastic enzyme activity and microtubule stability interactions.

APC Mutation marks an aggressive subtype of BRAF mutant colorectal cancers

This study identifies APC mutations as a marker of aggressive BRAF mutant colorectal cancers, associated with poor prognosis and enhanced tumor growth in mouse models.