BioengineeringbioRxiv
Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity
E. K. Leonard, J. Tomala, J. R. Gould…·J. B. Spangler
This paper develops an IL-2/antibody fusion protein that enhances immune effector cell activation and antitumor activity while reducing toxicity compared to natural IL-2.
DOI 10.1172/jci.insight.173469