V. Chandra

Developmental, regenerative, and behavioral dynamics in acoel reproduction

This study characterizes the reproductive anatomy, development, regeneration, and behavior of the acoel worm Hofstenia miamia, revealing size-dependent growth rules and long-term sperm storage and self-fertilization capabilities.

Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications in a common base culture media system

This study shows that tumoroids from six cancer types can be maintained long-term in a standardized serum-free medium, preserving their genetic and phenotypic features.

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell functionality

This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine

This study identifies CD73 as a key driver of immunosuppression in pancreatic ductal adenocarcinoma, showing its role in adenosine generation and tumor progression.

COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types.

The paper identifies COVID-19 risk variants associated with gene expression in multiple immune cell types, revealing potential mechanisms linking genetic risk to disease severity.

Colony expansions underlie the evolution of army ant mass raiding

The paper shows that mass raiding in army ants evolves from group raiding through colony size increases without changing individual behavioral rules.

Filamentous Bacteriophage Delay Healing of Pseudomonas-Infected Wounds

This study shows filamentous bacteriophage delays wound healing in Pseudomonas aeruginosa infections by inhibiting keratinocyte migration, supported by a patient cohort study.

Emergent behavioral organization in heterogeneous groups of a social insect

This study examines how group composition affects behavior and division of labor in clonal raider ants using experimental and theoretical approaches, showing that heterogeneity in genotype, age, and morphology leads to distinct behavioral patterns.

T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

This study shows that maturation increases dendritic cell cortical stiffness, which enhances T cell activation by reducing agonist dose requirements and is more pronounced in CD4+ T cells.