Pharmacology & ToxicologybioRxivPreprint
Progranulin maintains blood pressure and vascular tone dependent on EphrinA2 and Sortilin1 receptors and eNOS activation
A. Bruder-Nascimento, W. M. C. Awata, J. V. Alves…·T. Bruder-Nascimento
This study shows that progranulin regulates blood pressure and vascular tone through EphrinA2, Sortilin1 receptors, and eNOS activation, with PGRN deficiency causing hypertension and vascular dysfunction.
DOI 10.1101/2023.04.02.534563