R. M. Costa

This study shows that progranulin (PGRN) is essential for vascular contractility by regulating mitochondrial function, mitophagy, and redox signaling in vascular smooth muscle cells.

This study shows that CCL5/CCR5 contributes to aldosterone-induced hypertension, vascular injury, and renal damage by promoting inflammation and oxidative stress.

This study shows ethanol-induced vascular dysfunction is mediated by AT1 receptor activation and mitochondrial dysfunction, which can be mitigated by losartan.

This study shows that high testosterone increases NOX4 in endothelial cells, boosting H2O2 production to counteract testosterone-induced endothelial dysfunction and impaired migration.

This study shows that obese female mice have suppressed vascular Rho-kinase activation, which protects against cardiovascular issues, unlike male mice.

This study shows that progranulin regulates blood pressure and vascular tone through EphrinA2, Sortilin1 receptors, and eNOS activation, with PGRN deficiency causing hypertension and vascular dysfunction.

This study shows that circadian circuits regulated by light and the brain control ILC3 function, gut homeostasis, and metabolism.