A. Nelson

Ethylene and ROS Signaling Are Key Regulators of Lateral Root Development under Salt Stress in Tomato

This study identifies genes regulating lateral root development in tomato under salt stress, revealing ethylene and ROS signaling as key factors.

Structural basis of autoantibody binding in Neuromyelitis Optica

This study determines the structural basis of autoantibody binding to aquaporin-4 in NMO, revealing epitope diversity on tetrameric and higher-order assemblies.

Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

Development of a mobile, high-throughput, and low-cost image-based plant growth phenotyping system

The paper develops a low-cost image-based phenotyping system for plant growth and validates it using a cowpea diversity panel to identify drought resilience loci.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

The long and short of it: Benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies

This paper benchmarks viromics using Illumina, Nanopore, and PacBio sequencing technologies to assess their impact on viral community reconstruction and error rates.

Morphological Subprofile Analysis for Bioactivity Annotation of Small Molecules

This paper introduces subprofile analysis to predict the mode of action of small molecules using morphological profiling data, enabling rapid bioactivity annotation without requiring extensive reference compounds.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Platelet response to influenza vaccination reflects effects of aging

This study examines how aging and frailty affect platelet function before and after influenza vaccination, revealing age-related changes in activation and translation.

GLS1 is a Protective Factor Rather than a Molecular Target in ARID1A-Mutated Ovarian Clear Cell Carcinoma

The paper investigates GLS1 expression in ARID1A-mutated ovarian clear cell carcinoma and finds it is not correlated with ARID1A loss and is associated with better clinical outcomes.

Activating P2Y1 receptors improves function in arteries with repressed autophagy

This study shows that activating P2Y1 receptors enhances arterial function in conditions where endothelial autophagy is suppressed.

Frequent development of broadly neutralizing antibodies in early life in a large cohort of HIV-infected children

This study finds that HIV-infected children aged 1-3 years develop broadly neutralizing antibodies with breadth comparable to adults, and overall higher than adults, suggesting early life immune advantages for HIV vaccine development.

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

This study shows that Ror1/2 receptors are essential for cardiac myofibroblast differentiation and heart remodeling in response to pressure overload.

Metabolism Control in 3D Printed Living Materials

This study investigates oxygen permeability in 3D printed living materials and demonstrates their application in enhancing ethanol production in brewing.

Long-term assessment of ecosystem services at ecological restoration sites using Landsat time series

This study assesses long-term ecosystem service impacts of restoration interventions using Landsat time series and a BACI design in an arid landscape.

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

Physical confinement impacts cellular phenotype within living materials

The paper investigates how physical confinement in hydrogels affects yeast cell phenotype, finding that hydrogel composition alters cell size, growth patterns, and colony behavior.

Postpartum breast cancer progression is driven by semaphorin 7a mediated invasion and survival

This study shows SEMA7A drives postpartum breast cancer progression by enhancing invasion, survival, and tumor microenvironment changes, with potential therapeutic implications.

Interrogating mechanisms of ssDNA binding to a viral HUH-endonuclease by alanine scanning of an electrostatic patch

This study investigates the mechanism of ssDNA binding by a viral HUH-endonuclease through alanine scanning of an electrostatic patch, revealing key residues critical for binding specificity and activity.

Epistatic Transcription Factor Networks Differentially Modulate Arabidopsis Growth and Defense

The paper investigates how transcription factor networks modulate growth and defense in Arabidopsis, finding that their effects are conditional and not simply correlated.

Isolated occurrences of membrane perturbation by mechanosensing from weakly aggregating silver nanoparticles

This study investigates how silver nanoparticles interact with lipid vesicles under different conditions, finding that weak aggregation leads to isolated membrane perturbations.

Scarless gene tagging of transcriptionally silent genes in hiPSCs to visualize cardiomyocyte sarcomeres in live cells

The paper describes a CRISPR/Cas9 method to tag transcriptionally silent genes in hiPSCs with mEGFP, enabling visualization of sarcomeric proteins in live cardiomyocytes.

Retrosplenial cortex and its role in spatial cognition

This paper reviews the role of retrosplenial cortex in spatial cognition, classifying proposed functions into three categories and suggesting ways to test them.

Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization

The paper describes a CRISPR/Cas9 method to tag endogenous proteins in human iPSCs, generating 10 tagged lines with quality-controlled clones for cell biology research.