W. R. Schutt

This study establishes a murine model of age-dependent Powassan virus (POWV) lethality, revealing divergent neuroinflammatory cytokine responses in young and old mice that correlate with CNS viral clearance and disease severity.

This study shows that older mice are more susceptible to lethal Powassan virus infection, with increased viral load and severe brain damage compared to younger mice.

This study shows ZIKV induces TTP in endothelial and Sertoli cells, which post-transcriptionally inhibits IFNβ/λ secretion, promoting viral persistence.

This paper establishes a reverse genetics system for Powassan virus, identifies attenuating NS1 glycosylation sites, and creates an infectious NS1-GFP11 reporter virus to study viral functions.

This study isolates and characterizes POWVs from ticks, showing they spread cell-to-cell in culture and infect human brain endothelial cells and pericytes, leading to persistent infection and inflammatory responses.

This study shows that SARS-CoV-2 cannot directly infect primary human endothelial cells without recombinant ACE2 expression, but infection of ACE2-expressing endothelial cells induces inflammatory and procoagulative responses seen in COVID-19.