MicrobiologybioRxiv
Regulation of coronavirus nsp15 cleavage specificity by RNA structure
I. Salukhe, R. Choi, W. V. Voorhis…·J. L. Hyde
This study investigates how RNA secondary structure influences SARS-CoV-2 nsp15 endonuclease cleavage specificity, showing that stable structures protect RNA from cleavage and that uridine positioning within a pentaloop affects cleavage efficiency.
DOI 10.1371/journal.pone.0290675