Regulation of coronavirus nsp15 cleavage specificity by RNA structure
I. Salukhe, R. Choi, W. V. Voorhis, L. Barrett, J. L. Hyde
This study investigates how RNA secondary structure influences SARS-CoV-2 nsp15 endonuclease cleavage specificity, showing that stable structures protect RNA from cleavage and that uridine positioning within a pentaloop affects cleavage efficiency.
bioRxiv · May 12, 2023Microbiology