Regulators of health and lifespan extension in genetically diverse mice on dietary restriction
Andrea Di Francesco, Andrew G. Deighan, Lev Litichevskiy, Zhenghao Chen, Alison Luciano, Laura L. Robinson, Gaven Garland, Hannah Donato, Matthew J. Vincent, Will Schott, Kevin M. Wright, Anil Raj, G.V. Prateek, Martin N. Mullis, Warren G. Hill, , Gary A. Churchill
In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.
Nature · Oct 9, 2024Peer-reviewedGenetics✦ In-depth digest