David Botstein

The paper analyzes genetic diversity in naked mole-rats from Kenya and Ethiopia using whole-genome sequencing and a chromosome-scale genome assembly, revealing unexpected genetic divergence patterns.

This study investigates how the gut microbiome interacts with aging and dietary restriction in mice, finding that host genetics significantly influence microbiome features and that dietary restriction does not rejuvenate the microbiome.

In 937 genetically diverse female mice, caloric restriction and intermittent fasting extended lifespan, yet bodyweight resilience, immune and red-cell traits, not metabolic improvements, predicted longevity.

The paper aggregates and analyzes phenotypic data from yeast knock-out screens to identify gene functions and relationships, revealing new biological insights.

The paper analyzes replicative senescence in WI-38 cells using multi-omics data, finding early senescence markers, myofibroblast-like transitions, and YAP1/TEAD1 regulation.

The paper develops YETI, a yeast library with inducible gene expression, and shows low native expression can bias promoter-perturbing screens.

The paper identifies two minor yeast isozymes, ACO2 and PYK2, that have distinct roles in adapting to carbon availability through differential expression and functional advantages under specific metabolic conditions.