Cancer BiologybioRxiv
Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer
Y. Seo, S. Zhang, J. Jang…·J.-I. Park
This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.
DOI 10.1038/s41467-025-67078-9