J. Jang

Targeting MDSC-HTR2B to Improve Immune Checkpoint Inhibitors in Breast to Brain Metastasis

The paper identifies HTR2B on MDSCs as a target to enhance immune checkpoint inhibitors in breast-to-brain metastasis using clozapine and anti-PD-1 therapy.

Abo1 ATPase facilitates the dissociation of FACT from chromatin.

This study identifies Abo1 as a histone chaperone that facilitates FACT dissociation from chromatin through an ATP-dependent mechanism, essential for heterochromatin maintenance.

An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation

This paper develops a high-density epidural stimulation paddle with integrated electronics and evaluates its long-term performance in sheep.

PITPβ promotes COPI vesicle fission through lipid transfer and membrane contact formation

The paper identifies PITPβ's role in COPI vesicle fission by delivering phosphatidylcholine through membrane contacts, revealing a mechanism for lipid transfer in intracellular transport.

Size-Dependent Mechanoadaptation Enables Migration with Oversized Parasitic Cargo

The paper investigates how cells adapt to transport oversized parasitic cargo by reprogramming mechanical forces and subcellular architecture during migration.

A temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery and gene editing in primary human cells

This paper develops a temperature-sensitive and interferon-silent Sendai virus vector for CRISPR-Cas9 delivery, achieving high gene editing efficiency in human cells without triggering immune responses.

Cannabis sativa (Hemp) seed-derived peptides WVYY and PSLPA modulate the Nrf2 signaling pathway in human keratinocytes

This study investigates the antioxidant and antibacterial effects of hemp seed-derived peptides WVYY and PSLPA, showing their activation of the Nrf2 signaling pathway in human keratinocytes.

Mimicking the breast metastatic microenvironment: characterization of a novel syngeneic model of HER2+ breast cancer

The paper characterizes a novel syngeneic murine breast cancer model (NT2.5-LM) that exhibits rapid and widespread metastases, enabling study of metastatic progression and therapeutic responses.

High-throughput Microfluidic 3D Outer Blood-Retinal Barrier Model in a 96-Well Format: Analysis of Cellular Interactions and Barrier Function in Retinal Health and Disease

Unveiling the enigma of Brain-resident immune cells

This study identifies distinct brain-resident immune cell populations with unique transcriptional profiles, showing age-related changes and altered interactions in Alzheimer's disease.

Reproducing Left Ventricular Twist by Mimicking Myocardial Fiber Orientation Using 3D Bioprinting-assisted Tissue Assembly

This paper develops a 3D bioprinting-assisted method to create a chamber-like structure with myocardial fiber orientation, demonstrating left ventricular twist and structural-functional synchrony.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

Uremic toxin indoxyl sulfate induces trained immunity via the AhR-dependent arachidonic acid pathway in end-stage renal disease (ESRD)

This study shows indoxyl sulfate induces trained immunity in monocytes via AhR-dependent arachidonic acid pathway, contributing to inflammation in ESRD.

One-step pipetting of barcoded planar microparticles into compact monolayer assembling chip for efficient readout of multiplexed immunoassay

The paper presents a microfluidic chip for efficient multiplexed immunoassay readout using barcoded planar microparticles, achieving good accuracy with a single pipetting step.

Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi

This study tracks clinical and physiological changes in kra monkeys infected with P. knowlesi, revealing mechanisms of resilience to malaria.

Invasive Earthworms Alter Forest Soil Microbiomes and Nitrogen Cycling

This study shows invasive earthworms alter soil microbiomes and shift nitrogen cycling from nitrification to denitrification in hardwood forests.

Ubiquitin ligase component LRS1 and transcription factor CrHy5 act as a light switch for photoprotection in Chlamydomonas

The paper identifies LRS1 and CrHY5 as regulators of photoprotection gene expression in Chlamydomonas under high light conditions.

Loss of BubR1 Acetylation instigates Replication Stress leading to Complex Chromosomal Rearrangement in tumors

This study shows that loss of BubR1 acetylation causes replication stress and complex chromosomal rearrangements in tumors.

RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction point

This study shows RUNX3 regulates chromatin dynamics at the restriction point by opening and closing target loci through recruitment of chromatin modifiers, influencing cell cycle progression and tumor development.

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

The paper studies how small-molecule inhibitors block dengue virus membrane fusion by targeting the envelope protein's conformational change, showing that ~15 bound molecules per particle prevent fusion.