Author

G. Zou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Microbiology· 2 Bioengineering· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Approach:experimental assay· 6 Organism:human· 5 Organism:mouse· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Research Focus:drug response / drug discovery· 3 Assay:scRNA-seq· 3

Frequent Co-Authors

J. Zhang· 6 shared J.-I. Park· 6 shared K.-P. Ko· 6 shared S. Jun· 6 shared S. Zhang· 6 shared Y. Huang· 6 shared B. Kim· 5 shared K.-S. PARK· 3 shared

Activity by Year

2019-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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6 shared papersCancer Biology

J. Zhang

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Harnessing Gradients for Self-Assembly of Peptide-Based Nanocapsules: A Pathway to Advanced Drug Delivery Systems

H. Li, X. Qian, H. Mohanram, X. Han, H. Qi, G. Zou, F. Yuan, A. G. T. Miserez, Q. Yang, T. Liu, H. Gao, J. Yu

The paper describes the spontaneous formation of peptide-based nanocapsules through a solvent gradient-driven self-assembly process, offering a new approach for drug delivery systems.

bioRxiv · Jul 19, 2023 · PreprintBioengineering

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

B. Kim, S. Zhang, Y. Huang, K.-P. Ko, G. Zou, J. Zhang, S. Jun, K.-B. Kim, Y.-S. Jung, K.-S. PARK, J.-I. Park

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

bioRxiv · Apr 19, 2023 · PreprintCancer Biology

CDH1 loss defines distinct diffuse-gastric cancer subtype with T cell exhaustion and EZH2 regulon activation

G. Zou, Y. Huang, S. Zhang, K.-P. Ko, B. J. Kim, J. Zhang, V. Venkatesan, M. P. Pizzi, S. Jun, N. Niu, H. Wang, S. Song, J. A. Ajani, J.-I. Park

This study identifies two distinct subtypes of diffuse-type gastric cancer associated with CDH1 loss, highlighting T cell exhaustion and EZH2 regulon activation.

bioRxiv · Mar 23, 2023Cancer Biology

Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer

K.-P. Ko, S. Zhang, Y. Huang, B. Kim, G. Zou, S. Jun, J. Zhang, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Zhang, H. Nakagawa, J.-I. Park

This study defines ESCC subtypes based on tumor microenvironment transcriptional networks and predicts immunotherapy response using single-cell transcriptomics.

bioRxiv · Feb 15, 2023Cancer Biology

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

Y. Seo, S. Zhang, J. Jang, K.-P. Ko, K.-B. Kim, Y. Huang, D.-W. Kim, B. Kim, G. Zou, J. Zhang, S. Jun, W. Chu, N. A. Kirk, Y. E. Hwang, Y. H. Ban, , J.-I. Park

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

bioRxiv · Feb 15, 2023Cancer Biology

Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion

K.-P. Ko, Y. Huang, S. Zhang, G. Zou, B. Kim, J. Zhang, S. Jun, C. Martin, K. J. Dunbar, G. Efe, A. K. Rustgi, H. Nakagawa, J.-I. Park

This study identifies key genetic drivers of ESCC initiation and immune evasion using CRISPR/Cas9 in murine organoids and human scRNA-seq data.

bioRxiv · Oct 13, 2022Cancer Biology

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

B. Kim, Y. Huang, K.-P. Ko, S. Zhang, G. Zou, J. Zhang, M. Kim, D. Little, L. V. Ellis, M. Paschini, S. Jun, K.-S. Park, J. Chen, C. Kim, J.-I. Park

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

bioRxiv · Oct 11, 2022Cell Biology

A survey of Chinese pig farms and human healthcare isolates reveals separate human and animal MRSA populations

G. Zou, M. MATUSZEWSKA, M. Jia, J. ZHOU, X. Ba, J. DUAN, C. ZHANG, J. ZHAO, M. TAO, J. Fan, X. ZHANG, W. JIN, T. CUI, X. ZENG, M. JIA, , R. Zhou

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

bioRxiv · Aug 2, 2021 · PreprintMicrobiology

Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses including newly emerged coronavirus SARS-CoV-2

R. Xiong, L. Zhang, S. Li, Y. Sun, M. Ding, Y. Wang, Y. Zhao, Y. Wu, W. Shang, X. Jiang, J. Shan, Z. Shen, Y. Tong, L. Xu, Y. Chen, , K. Xu

This paper identifies two potent DHODH inhibitors with broad-spectrum antiviral activity against RNA viruses, including SARS-CoV-2, and suggests their potential clinical use.

Protein & Cell · Aug 4, 2020Peer-reviewedMicrobiology

FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

J. Zhong, J. Zhu, Z. Xu, G. Zou, J. Zhao, S. Jiang, W. Zhang, J. Xia, L. Yang, F. Li, Y. Gao, F. Chen, Y. Wu, D. Chen

FabriEVEs is a database that collects, classifies, and annotates endogenous viral elements in non-mammalian species, enabling comparative analysis and host-virus co-evolution studies.

bioRxiv · Jan 24, 2019 · PreprintEvolutionary Biology