Author

Y. Fichou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:protein structure· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

S. Han· 3 shared Y. Lin· 2 shared A. Goring· 1 shared A. P. Longhini· 1 shared C. Piersson· 1 shared G. C. Bazan· 1 shared K. Pounot· 1 shared K. S. Kosik· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

S. Han

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3 papers

Recent·Most cited

Mutations in tau protein promote aggregation by favoring extended conformations

K. Pounot, C. Piersson, A. Goring, M. Weik, S. Han, Y. Fichou

This study investigates how specific tau mutations promote amyloid aggregation by altering conformational properties and intermolecular interactions.

bioRxiv · May 12, 2023Biophysics

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Y. Lin, Y. Fichou, A. P. Longhini, L. C. Llanes, Y. Yin, G. C. Bazan, K. S. Kosik, S. Han

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

bioRxiv · Aug 5, 2020Biophysics

Liquid-liquid phase separation and fibrillization of tau are independent processes with overlapping conditions

Y. Lin, Y. Fichou, Z. Zeng, N. Y. Hu, S. Han

This study shows that tau's liquid-liquid phase separation and amyloid aggregation are independent processes that occur under overlapping conditions.

bioRxiv · Jul 13, 2019Biophysics