Z. Zeng

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Genetic dissection of the tissue-specific roles of type III effectors and phytotoxins in the pathogenicity of Pseudomonas syringae pv. syringae to cherry

This study investigates the tissue-specific roles of type III effectors and phytotoxins in Pseudomonas syringae pv. syringae pathogenicity to cherry, finding that toxins are critical for fruit infection while effector redundancy complicates disease progression.

Determination and characterization of papillomaviurs and parvovirus causing mass mortality of Chinese tongue sole (Cynoglossus semilaevis) in China

This study identifies two novel viruses, CsPaV and CsPV, as the causative agents of mass mortality in farmed Chinese tongue sole, revealing their co-infection and potential for further research on viral interactions.

Biosynthesis of H-GDGTs linked to ocean oxygen deficiency

The paper identifies the gene responsible for biosynthesizing H-GDGTs and shows its association with oxygen-deficient environments.

CCL2 and Neuronal Inflammation: Implications for Neurodegenerative Diseases

This review examines the role of CCL2 in microglial activation and neuronal inflammation, linking it to neurodegenerative diseases and discussing therapeutic strategies.

Speckle rheological spectroscopy reveals wideband viscoelastic spectra of biological tissues

This paper introduces SHEARS, a technique to measure wideband viscoelastic properties of biological tissues, revealing previously inaccessible mechanical behavior across a broad frequency range.

Integrated Epigenetic and Transcriptomic Profiling Reveals Dynamic Regulatory Networks Driving Retinoblastoma Pathogenesis

This study uses single-cell multi-omics to map epigenetic and transcriptomic changes in retinoblastoma, identifying key regulators and potential drug targets.

Long-B prokaryotic Argonaute systems employ various effectors to confer immunity via abortive infection

The paper identifies long-B prokaryotic Argonaute systems as cell suicide mechanisms that use effector proteins to eliminate invading nucleic acids through abortive infection.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

The production of diverse brGDGTs by an Acidobacterium allows a direct test of temperature and pH controls on their distribution

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

Fate mapping melanoma persister cells through regression and into recurrent disease in adult zebrafish

The paper tracks melanoma persister cells in zebrafish to show their role in recurrent disease.

A short prokaryotic argonaute cooperates with membrane effector to confer antiviral defense

The paper identifies a short prokaryotic argonaute (pAgo) in Sulfolobus islandicus that, along with Aga1 and Aga2, provides antiviral defense through abortive infection.

Data-driven discovery of targets for bipotent anticancer drugs identifies Estrogen Related Receptor Alpha

BipotentR identifies immune-metabolic regulators for bipotent anticancer drugs, demonstrating ESRRA inhibition's effects on tumor metabolism and immune mechanisms.

Modular multilevel TMS device with wide output range and ultrabrief pulse capability for sound reduction

This paper introduces a modular multilevel TMS device capable of generating a wide range of pulse shapes and widths, enabling quieter TMS through shorter pulses.

Impact of vitamin B12 on rhamnose metabolism, stress defense and in-vitro virulence of Listeria monocytogenes

This study shows that vitamin B12 enhances anaerobic growth and virulence of L. monocytogenes on rhamnose by activating the pdu BMC pathway and upregulating stress defense and virulence factors.

Impact of bacterial microcompartment-dependent ethanolamine and propanediol metabolism on Listeria monocytogenes interactions with Caco-2 cells

This study investigates how bacterial microcompartment-dependent ethanolamine and propanediol metabolism in Listeria monocytogenes affects its interaction with Caco-2 cells, finding enhanced translocation efficacy with active BMCs.

Anaerobic growth of Listeria monocytogenes on rhamnose is stimulated by Vitamin B12 and bacterial microcompartment dependent 1,2-propanediol utilization

This study shows that vitamin B12 activates the pdu pathway in L. monocytogenes, enabling anaerobic growth on rhamnose via 1,2-propanediol degradation and BMC formation.

An angiosperm NLR atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

Self-assembling SARS-CoV-2 nanoparticle vaccines targeting the S protein induces protective immunity in mice

This study develops self-assembling SARS-CoV-2 nanoparticle vaccines that induce protective immunity in mice through subcutaneous and oral administration.

Exposure of mammary cells to lipid activates gene expression changes associated with ER-negative breast cancer via chromatin remodeling.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

Bacterial microcompartments linked to the flavin-based extracellular electron transfer drives anaerobic ethanolamine utilization in Listeria monocytogenes

This study shows that Listeria monocytogenes uses bacterial microcompartments (BMCs) for anaerobic ethanolamine catabolism, which is linked to flavin-based extracellular electron transfer to balance redox states.

Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

This study identifies TFR1, SAHH, and HV307 as potential biomarkers for colorectal cancer screening through proteomics analysis of pre-cancerous to cancerous tissues.

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger Cyclin K degradation

This paper discovers a molecular glue, HQ461, that promotes CDK12-DDB1 interaction, leading to Cyclin K degradation and cell death.

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

Liquid-liquid phase separation and fibrillization of tau are independent processes with overlapping conditions

This study shows that tau's liquid-liquid phase separation and amyloid aggregation are independent processes that occur under overlapping conditions.

Inducible Plasmid Self-Destruction (IPSD) assisted genome engineering in lactobacilli and bifidobacteria

This paper introduces IPSD, a genome engineering method for lactobacilli and bifidobacteria using inducible plasmid self-destruction to enable gene knock-out and knock-in.

Deep learning for cancer type classification

This study introduces DeepCues, a deep learning model that improves cancer type classification using DNA sequencing data, achieving 77.6% accuracy on TCGA data and showing significant improvement over conventional methods.