Author

A. P. Longhini

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

K. S. Kosik· 2 shared S. Han· 2 shared A. Dubose· 1 shared G. C. Bazan· 1 shared J.-E. Shea· 1 shared K. Tsay· 1 shared L. C. Llanes· 1 shared M. S. Shell· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

K. S. Kosik

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintNov 28, 2023

Tau P301L mutation promotes core 4R tauopathy fibril fold through near-surface water structuring and conformational rearrangement

M. Vigers, S. Lobo, S. Najafi…·S. Han

This paper identifies a tau peptide fragment that forms seeding-competent fibrils and shows how the P301L mutation facilitates its aggregation into 4R tauopathy-like structures.

DOI 10.1101/2023.11.28.568818

humanproteomics

𝕏 PostBluesky

BiophysicsbioRxivAug 5, 2020

Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau

Y. Lin, Y. Fichou, A. P. Longhini…·S. Han

This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.

DOI 10.1016/j.jmb.2020.166731

protein structureexperimental assay

𝕏 PostBluesky