BiophysicsbioRxiv
Liquid-liquid phase separation of tau driven by hydrophobic interaction facilitates fibrillization of tau
Y. Lin, Y. Fichou, A. P. Longhini…·S. Han
This study compares hydrophobic and electrostatically driven liquid-liquid phase separation of tau, showing that hydrophobic interactions promote amyloid fibril formation while electrostatic interactions do not.
DOI 10.1016/j.jmb.2020.166731