Author

Y. Hefner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:bacteria (other)· 2 Organism:E. coli· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. V. Sastry· 4 shared B. O. Palsson· 3 shared R. Szubin· 3 shared S. Poudel· 2 shared S. Xu· 2 shared V. Nizet· 2 shared Y. Gao· 2 shared A. Campeau· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

A. V. Sastry

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Proteome allocation is linked to transcriptional regulation through a modularized transcriptome

A. Patel, D. McGrosso, Y. Hefner, A. Campeau, A. V. Sastry, S. Maurya, K. Rychel, D. J. Gonzalez, B. O. Palsson

The paper investigates modularization of bacterial transcriptomes and proteomes to uncover relationships between their compositions and regulatory mechanisms.

bioRxiv · Feb 20, 2023Bioengineering

Coordination of CcpA and CodY regulators in Staphylococcus aureus USA300 strains

S. Poudel, Y. Hefner, R. Szubin, A. V. Sastry, Y. Gao, V. Nizet, B. O. Palsson

This paper uses ICA to modularize the TRN of S. aureus USA300 and combines it with a metabolic model to show coordination between CcpA and CodY in regulating carbon and amino acid metabolism.

bioRxiv · May 25, 2022Microbiology

Decomposition of transcriptional responses provides insights into differential antibiotic susceptibility

A. V. Sastry, N. Dillon, S. Poudel, Y. Hefner, S. Xu, R. Szubin, A. Feist, V. Nizet, B. Palsson

The paper investigates how media composition affects antibiotic susceptibility in E. coli using transcriptomics and machine learning, identifying key regulators and shifts in respiration and iron availability.

bioRxiv · May 4, 2020 · PreprintMicrobiology

Adaptive laboratory evolution of Escherichia coli under acid stress

B. Du, C. A. Olson, A. V. Sastry, X. Fang, P. V. Phaneuf, K. Chen, M. Wu, R. Szubin, S. Xu, Y. Gao, Y. Hefner, A. M. Feist, B. O. Palsson

This study evolves E. coli under acid stress and identifies genetic and expression changes that enhance acid tolerance.

bioRxiv · Jun 4, 2019Microbiology