S. Poudel

Negative Synergistic Effects of Drought and Heat During Flowering and Seed Setting in Soybean

This study examines the combined effects of drought and heat on soybean physiology, yield, and gene expression during flowering and seed setting, finding that combined stress has more severe negative impacts than individual stresses.

Nor-LAAM loaded PLGA Microparticles for Treating Opioid Use Disorder

This paper develops sustained-release nor-LAAM-loaded PLGA microparticles for OUD treatment, showing prolonged drug release and reduced fentanyl choice and withdrawal in rats.

Printing double network tough hydrogels using Temperature-Controlled Projection Stereolithography (TOPS)

This paper introduces a method to print double-network hydrogels with superior mechanical properties using temperature-controlled projection stereolithography.

Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

The paper identifies carbon sources that regulate hemolytic toxin expression in Streptococcus pyogenes using transcriptome-wide independent component analysis.

Coordination of CcpA and CodY regulators in Staphylococcus aureus USA300 strains

This paper uses ICA to modularize the TRN of S. aureus USA300 and combines it with a metabolic model to show coordination between CcpA and CodY in regulating carbon and amino acid metabolism.

Design of a Minimal di-Nickel Hydrogenase Peptide

The paper designs a minimal di-nickel hydrogenase peptide capable of producing molecular hydrogen from protons under various conditions, suggesting early enzymes evolved from simple peptides.

Meta-omics-aided isolation of an elusive anaerobic arsenic-methylating soil bacterium

The paper isolates an anaerobic arsenic-methylating bacterium using meta-omics approaches to overcome challenges in functional isolate identification.

Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains

This study identifies the CodY regulon in two closely related S. aureus USA300 strains, revealing conserved and strain-specific regulatory patterns and metabolic roles of CodY.

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions

This study examines how MDR A. baumannii responds to azithromycin in different growth conditions using multiple analytical techniques.

Identifying the effect of vancomycin on HA-MRSA strains using bacteriological and physiological media

The paper examines vancomycin's effect on HA-MRSA USA100 strains using bacteriological and physiological media through growth curves, RNA sequencing, and exo-metabolomics.

Decomposition of transcriptional responses provides insights into differential antibiotic susceptibility

The paper investigates how media composition affects antibiotic susceptibility in E. coli using transcriptomics and machine learning, identifying key regulators and shifts in respiration and iron availability.

Profiling the effect of nafcillin on HA-MRSA D592 using bacteriological and physiological media

This study investigates how nafcillin affects HA-MRSA D592 in different media types, revealing media-dependent antibiotic activity through multi-dimensional analysis.

Pangenome analytics reveal two-component systems as conserved targets in ESKAPEE pathogens

This study uses pangenome analytics to analyze two-component systems in ESKAPEE pathogens, revealing their phylogenetic distribution and sequence variation, and highlights their potential as targets for antibiotic resistance.