Sustained pigmentation causes DNA damage and invokes translesion polymerase Pol κ for repair in melanocytes
V. Natarajan, S. Khanna, M. Ghazi…·R. S. Gokhale
This study shows sustained melanogenesis causes DNA damage in melanocytes, invokes Pol κ for repair, and links Pol κ activity to genome instability and mutational load in melanoma.