Author

Y. Jacob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:Arabidopsis· 3 Assay:DNA methylation· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

C. LeBlanc· 3 shared A. Blondel· 1 shared A. Meignie· 1 shared A. O'Brien· 1 shared A. Poulet· 1 shared A. Sarkiss· 1 shared A. V. Komarova· 1 shared A. Zettor· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersPlant Biology

C. LeBlanc

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Author profile →

5 papers

Recent·Most cited

Induction of T-DNA amplification by retrotransposon-derived sequences

L. Dickinson, W. Yuan, C. LeBlanc, G. Thomson, S. Wang, Y. Jacob

This study shows that retrotransposon-derived sequences in T-DNA can amplify transgene copy number in Arabidopsis, increasing targeted mutagenesis and gene targeting frequency.

bioRxiv · Mar 5, 2023 · PreprintPlant Biology

Systematic histone H4 replacement in Arabidopsis thaliana reveals a role for H4R17 in regulating flowering time

E. T. Corcoran, C. LeBlanc, M. Arias Tsang, A. Sarkiss, Y. Hu, U. V. Pedmale, Y. Jacob

This paper develops a genetic strategy in Arabidopsis thaliana to replace histone H4 with mutants, identifies H4R17 as a regulator of flowering time via ISWI complex interaction, and provides a resource for studying histone function.

bioRxiv · Jan 17, 2022Plant Biology

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.-Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, D. Courtney, A. O'Brien, S. Baker, C. Isel, F. Agou, Y. Jacob, A. Blondel, N. Naffakh

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.

bioRxiv · Dec 18, 2021Microbiology

H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation

J. Dong, C. LeBlanc, A. Poulet, B. Mermaz, G. Villarino, K. M. Webb, V. Joly, J. Mendez, P. Voigt, Y. Jacob

This study identifies GCN5 as a mediator of transcriptional de-repression and genomic instability in plants lacking H3.1K27me1, revealing its role in maintaining genome stability through histone acetylation regulation.

bioRxiv · Jul 17, 2020Plant Biology

Proteomic Analysis Uncovers Measles Virus Protein C Interaction with p65/iASPP/p53 Protein Complex

A. Meignie, C. Combredet, M. Santolini, I. A. Kovacs, T. Douche, Q. Giai Gianetto, H. Eun, M. Matondo, Y. Jacob, R. Grailhe, F. Tangy, A. V. Komarova

The paper identifies p65/iASPP/p53 protein complex as a specific interaction partner of measles virus protein C, revealing its role in regulating cell death and innate immunity pathways.

bioRxiv · May 8, 2020Microbiology