Cancer BiologybioRxiv
Pseudogene-mediated DNA demethylation leads to oncogene activation
J. Kwon, Y. V. Liu, C. Gao…·D. G. Tenen
This study identifies a mechanism by which pseudogene 5 induces DNA demethylation and reactivates the oncogene SALL4 in hepatocellular carcinoma, linking HBV infection to HCC progression.
DOI 10.1126/sciadv.abg1695