Yelena S. Tarasova

This study shows that aging impairs proteostatic mechanisms in mice with cardiac-specific over-expression of adenylyl cyclase VIII, leading to accelerated heart aging and cardiomyopathy.

The paper compares age-related molecular changes in left ventricle and sinoatrial node cells from young and old C57 mice using transcriptomic analysis to identify age-associated gene expression patterns and regulatory mechanisms.