Z. A. Rollins

This paper introduces a microfluidic method to assess B cell affinity to antigens under force, showing it can enrich high-affinity B cells and correlate with solution-based antibody affinity.

The paper presents a pipeline to predict TCR-pMHC structures and rank TCRs for immunotherapeutic applications using computational methods.

This study shows that mutations in pMHC binding groove peptides affect TCR-pMHC bond strength and duration, correlating with immunogenicity through physiochemical features.

This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.

This study develops a 3D organ-on-a-chip model of human bone marrow niches that supports hematopoietic stem cell maintenance, differentiation, and myeloid progenitor egress.