Evolutionary BiologybioRxiv
Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.
A. M. Taverner, L. Yang, Z. J. Barile…·P. Andolfatto
The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.
DOI 10.7554/elife.48224