D. Wei

Dynamic Modeling of Antibody Repertoire Reshaping in Response to Viral Infections

This study uses mathematical modeling to show that viral infections reshape the antibody repertoire through the proliferation of high-affinity antibody pools and contraction of low-affinity pools, with self-antigens maintaining antibody persistence.

Anatomics MLT, an AI tool for large scale quantification of ultrastructural traits

The paper develops an AI tool for quantifying ultrastructural traits from 3D microscopic datasets and improves fixation protocols for plants.

Colorectal ALOX15 as a host factor determinant of EPA and DHA effects on colorectal carcinogenesis

This study shows that ALOX15 expression modulates EPA and DHA effects on colorectal carcinogenesis by promoting resolvin generation, which suppresses pro-tumorigenic inflammation.

FGF2 binds to the allosteric site (site 2) and activates integrin αIIbβ3 and FGF1 binds to site 2 but suppresses integrin activation by FGF2: A potential mechanism of anti-thrombotic action of FGF1.

This study shows FGF2 activates integrin αIIbβ3 via site 2, while FGF1 binds site 2 but inhibits FGF2-induced activation, suggesting FGF1's anti-thrombotic mechanism.

FGF2 binds to the allosteric site (site 2) and activates αvβ3 integrin and FGF1 binds to site 2 but suppresses integrin activation by FGF2: a potential mechanism of anti-inflammatory action of FGF1

This study shows FGF2 activates αvβ3 integrin via site 2, while FGF1 binds site 2 but suppresses integrin activation, suggesting FGF1's anti-inflammatory action is through blocking site 2.

Mathematical Modelling Indicates Th-cell Targeted Antibody-Dependent Cellular Cytotoxic Is a Crucial Obstacle Hurdling HIV Vaccine Development

This paper uses mathematical modeling to show that ADCC targeting Th cells hinders HIV vaccine development by damaging immune responses and reducing vaccine effectiveness.

Murine Alveolar Macrophages Rapidly Accumulate Intranasally Administered SARS-CoV-2 Spike Protein leading to Neutrophil Recruitment and Damage

This study shows that intranasal SARS-CoV-2 Spike protein is rapidly taken up by murine alveolar macrophages, leading to neutrophil recruitment and tissue damage.

CALCIUM-DEPENDENT PROTEIN KINASE32 regulates cellulose biosynthesis through post-translational modification of cellulose synthase

The paper identifies CPK32 as a kinase that phosphorylates CESA3, affecting CSC motility and stability, thereby regulating cellulose biosynthesis.

Modeling Microtubule-Cytoplasm Interaction in Plant Cells

The paper develops a computational model to study microtubule-cytoplasm interaction in plant cells, showing microtubules align orthogonally to cell elongation and matching experimental results.

FOXP2 confers oncogenic effects in prostate cancer through activating MET signalling

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

Two Competing Guilds as a Core Microbiome Signature for Health Recovery

The paper identifies two competing bacterial guilds in the gut microbiome that correlate with host health conditions and can classify multiple diseases across diverse populations.

Combined effects of 12-week yoga warm-up on athletic performance in male high school track and field athletes

This study compares 12-week yoga and dynamic stretching warm-ups in male high school athletes, finding yoga improves flexibility and 800m speed more than stretching.

A cross-sectional study of the commercial plant-based landscape across the US, UK and Canada.

This study analyzes the nutritional content of commercial plant-based products across the US, UK, and Canada, finding they are generally lower in saturated fat and sodium than meat-based options but require improvement.

Ligand-induced unfolding mechanism of an RNA G-quadruplex

This study investigates the mechanism by which TMPyP4 induces unfolding of RNA G-quadruplexes using simulations and experiments, revealing a two-state interaction mechanism.

CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 variants

This study shows that CD147 antibody inhibits SARS-CoV-2 infection and cytokine storm in variants by blocking viral entry and reducing inflammatory responses.

The Wood Image Analysis and Dataset (WIAD): open-access visual analysis tools to advance the ecological data revolution

The paper introduces WIAD, an open-source tool for visual analysis of wood images to improve transparency and reproducibility in ecological studies.

Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

Changes in nitrogen pools in the maize-soil system after urea or straw application to a typical intensive agricultural soil: A 15N tracer study

This study compares nitrogen dynamics in maize-soil systems with urea and urea-straw treatments, finding that straw enhances nitrogen availability through rhizosphere interactions.

Structural basis for repurpose and design of nucleoside drugs for treating COVID-19

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

Molecularly Targeted Magnetic Resonance Imaging and Spectroscopy

This paper introduces a novel MRI/MRS method that selectively images specific metabolites by using nuclear spin singlet states, demonstrating molecular selectivity for endogenous molecules like N-acetylaspartate and dopamine.

Lectin-like Intestinal Defensin Inhibits 2019-nCoV Spike binding to ACE2

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

Channel Embedding for Informative Protein Identification from Highly Multiplexed Images

This paper introduces a channel embedding method for interpreting highly multiplexed biomedical images, demonstrating its effectiveness on synthetic data and breast cancer cell images.

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

This study identifies CD147 as a novel receptor for SARS-CoV-2 spike protein, showing that Meplazumab inhibits viral entry with EC50 24.86 g/mL and confirms the interaction through binding assays and microscopy.

Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.

Assessment of the optimum fertilizer rates and planting density for soybean production in China

The paper evaluates optimal fertilizer rates and planting density for soybean production in China using field experimental data, finding varying optimal rates for spring and summer soybean.

Adaptive substitutions underlying cardiac glycoside insensitivity in insects exhibit epistasis in vivo.

The paper investigates how adaptive substitutions in Na+,K+-ATPase affect cardiac glycoside insensitivity in insects, revealing epistatic interactions that constrain evolution.

Nanoscale fracture of defective popgraphene monolayer

This study investigates the fracture behavior of defective popgraphene using molecular dynamics and continuum modeling, revealing how different defect types affect fracture stress.

KPNA2 promotes cellular proliferation and inhibits apoptosis in the Saos-2 osteosarcoma cell line

This study shows KPNA2 is highly expressed in osteosarcoma tissues and its reduction inhibits cell proliferation and promotes apoptosis in Saos-2 cells.

A chemoproteomic portrait of the oncometabolite fumarate

This study maps fumarate's covalent targets using chemoproteomic probes and identifies cysteine residues affected by fumarate or FH mutations in HLRCC cells.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.