S. C. Watkins

This study identifies an alternative splice variant of Drp1 in ovarian cancer that promotes metastasis and chemoresistance by altering mitochondrial dynamics.

This study identifies the AKT2/SIRT5/TFEB pathway as a therapeutic target for atrophic AMD by showing its role in lysosomal dysfunction and drusen formation in RPE cells.

This paper introduces IPOLπ, an improved version of polarized light microscopy that enhances collagen orientation discrimination and imaging speed in ocular tissues.

This paper genetically engineers an endothelial niche in human kidney organoids to enhance vascularization, maturation, and the emergence of new cell types.

This study shows carcinoma-associated mesenchymal stem cells promote ovarian cancer metastasis by transferring mitochondria to cancer cells, increasing tumor heterogeneity and enhancing survival.

This study identifies the protist Tritrichomonas arnold as a protector against virus-induced loss of oral tolerance to gluten, showing it reduces inflammation in dendritic cells and is underrepresented in celiac disease patients.

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

The paper shows CPSF6 and CypA interact to regulate HIV-1 capsid trafficking and infection by affecting capsid-CPSF6 complex formation and stability.

This study identifies a systemic immune dysfunction in cancer patients driven by IL6 and IL8, leading to CD8+ T cell dysfunction and poor prognosis.

The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.

This study uses ribbon-scanning confocal microscopy to compare the outflow tract anatomy of human and porcine eyes, finding humans have fewer and larger collector channels.

This study shows that Blimp-1 in adipose Tregs suppresses IL-10, reducing beiging and increasing obesity risk, while its ablation improves insulin sensitivity and reduces weight in mice.

This study shows PTBA enhances AKI recovery in zebrafish by promoting RTEC dedifferentiation and reducing fibrosis, with effects also observed in cardiac injury.

The paper identifies the N-cadherin interactome in primary cardiomyocytes using proximity proteomics, revealing over 350 proteins, many unique to CDH2.

This study shows that PIKfyve inhibition causes lysosome coalescence, leading to fewer enlarged lysosomes, and that TFEB-mediated biosynthesis does not drive this swelling.

The paper develops TRApHIC, a genetically targeted pH sensor for studying receptor trafficking, revealing agonist-specific differences in B2AR endocytosis and recycling.