Cell BiologybioRxiv
The laminin-keratin link shields the nucleus from mechanical deformation and signalling
Z. Kechagia, P. Saez, M. Gomez-Gonzalez…·P. Roca-Cusachs
This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.
DOI 10.1038/s41563-023-01657-3