The paper develops a multi-scale computational model of adhesion complexes to study how individual molecules respond to mechanical forces and control cell traction forces, aligning with experimental data.

bioRxiv · Jan 9, 2023Biophysics

Cell response to extracellular matrix energy dissipation outweighs rigidity sensing

C. Huerta-Lopez, A. Clemente-Manteca, D. Velazquez-Carreras, F. M. Espinosa, J. G. Sanchez, P. Saez, A. Martinez-del-Pozo, M. Garcia-Garcia, S. Martin-Colomo, A. Rodriguez-Blanco, R. Esteban-Gonzalez, F. M. Martin-Zamora, L. Gutierrez-Rus, R. Garcia, P. Roca-Cusachs, , J. Alegre-Cebollada

The paper shows that substrate energy dissipation suppresses YAP mechanosensing more than stiffness cues in cell mechanotransduction.

bioRxiv · Nov 16, 2022Bioengineering

Brain tissue mechanics is governed by microscale relations of the tissue constituents

P. Saez, C. Borau, N. Antonovaite, K. Franze

The paper develops a model to predict brain tissue mechanics by considering the non-affine deformations of individual constituents, showing that their assembly, not just stiffness, determines tissue properties.

bioRxiv · Oct 19, 2022Biophysics

A full computational model of cell motility: Early spreading, cell migration and competing taxis

J. Betorz, G. R. Bokil, S. M. Deshpande, S. Kulkarni, D. Rolando, C. Venturini, P. Saez

This paper develops a computational model of cell motility that explains migration types and signal competition, showing chemotaxis dominates durotaxis but can be overridden under specific conditions.

bioRxiv · Sep 28, 2022 · PreprintBiophysics

Positive, negative and engineered durotaxis

P. Saez, C. Venturini

This study explains positive and negative durotaxis through asymmetric cell adhesion dynamics and provides a framework to engineer cell migration.

bioRxiv · Sep 26, 2022 · PreprintBiophysics

A Shape Sensing Mechanism driven by Arp2/3 and cPLA2 licenses Dendritic Cells for Migration to Lymph Nodes in Homeostasis

Z. Alraies, C. A. Rivera, M.-G. Delgado, D. Sanseau, M. Maurin, R. Amadio, G. Maria Piperno, G. Dunsmore, A. Yatim, L. Lacerda Mariano, P. Saez, M. Gratia, O. Lamiable, A. Moreau, A. Williart, , A.-M. Lennon-Dumenil

The paper identifies a shape sensing mechanism in dendritic cells that links cell motility to CCR7 expression, enabling migration to lymph nodes through ARP2/3-cPLA2 signaling.

bioRxiv · Aug 9, 2022Cell Biology

The laminin-keratin link shields the nucleus from mechanical deformation and signalling

Z. Kechagia, P. Saez, M. Gomez-Gonzalez, M. Zamarbide, I. Andreu, T. Koorman, A. E. M. Beedle, P. W. B. Derksen, X. Trepat, M. Arroyo, P. Roca-Cusachs

This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.

bioRxiv · Mar 1, 2022Cell Biology

Evaluating features of scientific conferences: A call for improvements

S. Sarabipour, B. Schwessinger, F. N. Mumoki, A. D. Mwakilili, A. Khan, H. J. Debat, P. Saez, S. Seah, T. Mestrovic

The paper evaluates features of scientific conferences and identifies areas for improvement, including diversity, inclusivity, and environmental sustainability.

Nature Human Behaviour · Mar 15, 2021Peer-reviewedScientific Communication & Education

HIF2α is a Direct Regulator of Neutrophil Motility

S. Sormendi, M. Deygas, A. Sinha, A. Krueger, I. Kourtzelis, G. Le Lay, M. Bernard, P. Saez, M. Gerlach, K. Franke, A. Meneses, M. Kraeter, A. Palladini, J. Guck, U. Coskun, , B. Wielockx

This study identifies HIF2α as a regulator of neutrophil motility through the PHD2-HIF2-RhoA axis, enhancing migration in hypoxic environments during inflammation.

bioRxiv · Jun 5, 2020Immunology