Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance
J. Huang, H. Tao, P. G. Yancey, Z. Leuthner, L. May-Zhang, J.-Y. Jung, Y. Zhang, L. Ding, V. Amarnath, D. Liu, S. Collins, S. S. Davies, M. F. Linton
This study shows that scavenging reactive dicarbonyls with PPM reduces atherosclerosis and insulin resistance in Ldlr-/- mice by improving HDL function and reducing inflammation.
bioRxiv · Nov 18, 2022Pharmacology & Toxicology