ImmunologybioRxiv
The splicing isoform Foxpdelta2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis
G. Qianchong, Z. Xiufeng, G. Jie…·Z. Xuyu
This study shows that the Foxp3{Delta}2 isoform, generated by alternative splicing, alters Treg function by enhancing DNA binding and affecting homeostasis in different Treg subsets.
DOI 10.1016/j.celrep.2023.112877