X. Wei

Super-Enhancer Driven ZFP36L1 Promotes PD-L1 Expression in Infiltrative Gastric Cancer

This study identifies ZFP36L1, driven by a super-enhancer, as a key regulator of PD-L1 expression in infiltrative gastric cancer, contributing to immune escape.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

Insulin regulates lymphatic endothelial function via palmitoylation

This study investigates how insulin regulates lymphatic endothelial function through palmitoylation, identifying CD36 as a mediator of this process.

Molecular Basis for RNA Cytidine Acetylation by NAT10

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

A community-curated, global atlas of Bacillus cereus sensu lato genomes for epidemiological surveillance

The paper develops BTyperDB, a global atlas of Bacillus cereus sensu lato genomes, to improve pathogen surveillance and identify emerging lineages.

Lithocholic acid phenocopies rejuvenating and life-extending effects of calorie restriction

This study identifies lithocholic acid as a metabolite that mimics calorie restriction's anti-aging effects in multiple species through AMPK activation.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation

This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.

Population genetic analyses of longitudinal vaginal microbiome reveal racioethnic evolutionary dynamics and prevailing positive selection of Lactobacillus adhesins

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

Comparative single-cell analysis reveals IFN-γ as a driver of respiratory sequelae post COVID-19

This study compares single-cell RNA sequencing data from human and mouse PASC samples to identify IFN-γ as a driver of respiratory sequelae post COVID-19.

Progressive community, biogeochemical and evolutionary remodeling of the soil microbiome underpins long-term desert ecosystem restoration

This study examines the long-term microbial changes in desert soil during ecological restoration, finding shifts in community structure, functional diversity, and biogeochemical cycles over 17 years.

Turnover of retroelements and satellite DNA drives centromere reorganizationover short evolutionary timescales in Drosophila

The paper investigates centromere reorganization in Drosophila species, finding rapid turnover of retroelements and satellite DNA over short evolutionary timescales.

AMPK targets PDZD8 to trigger carbon source shift to glutamine

This paper identifies AMPK's role in shifting carbon utilization from glucose to glutamine via PDZD8 phosphorylation, enhancing glutaminolysis and extending lifespan in C. elegans and mice.

Sorcin-STAT3-Serpin E1/CCL5 axis can be the trigger of pancreatic cancer-associated new-onset diabetes

This study identifies a Sorcin-STAT3-Serpin E1/CCL5 signaling axis that drives pancreatic cancer-associated new-onset diabetes by impairing beta-cells and elevating serpin E1 levels in peripheral blood.

A framework for Frizzled-G protein coupling and implications to the Wnt-PCP signaling pathways

This study presents cryo-EM structures of FZD6, FZD3, and FZD1 in active and inactive states, revealing a shared activation framework and potential crosstalk between G-protein binding and Wnt-PCP signaling.

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

FSCN1 is critical for HNSCC

This study identifies FSCN1 as a prognostic marker and critical factor for migration in HNSCC through expression analysis and functional assays.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

This study shows that the SEL1L-HRD1 interaction is essential for HRD1 ERAD complex function, as its disruption leads to developmental defects and cerebellar ataxia in mice.

Intravital microscopy of satellite cell dynamics and their interaction with myeloid cells during skeletal muscle regeneration

This study uses intravital microscopy to examine satellite cell dynamics and interactions with myeloid cells during skeletal muscle regeneration, revealing that direct contact is not required for early activation but is important for proliferation and differentiation.

The splicing isoform Foxpdelta2 releases the autoinhibitory conformation and differentially regulates tTregs and pTregs homeostasis

This study shows that the Foxp3{Delta}2 isoform, generated by alternative splicing, alters Treg function by enhancing DNA binding and affecting homeostasis in different Treg subsets.

The episodic resurgence of highly pathogenic avian influenza H5 virus

This study tracks the resurgence of H5N1 avian influenza, identifying key events and genetic changes that contributed to its global spread from 2016/17 to 2021/22.

Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

Identification of a self-renewing muscle satellite cell state by single-cell chromatin accessibility profiling

The paper identifies a self-renewing muscle satellite cell state using single-cell chromatin accessibility profiling and shows TGFBR3 as a marker for these cells.

ZmEREB57 regulates OPDA synthesis and enhances salt stress tolerance through two distinct signal pathways in Zea mays

This study identifies ZmEREB57 as a maize AP2/ERF transcription factor that enhances salt stress tolerance by regulating OPDA and JA signaling through two distinct pathways.

Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

This study shows that targeted degradation of PCNA via biodegraders leads to more effective anti-proliferative effects and programmed cell death compared to stoichiometric inhibition.

Collateral cleavage of 28s rRNA by RfxCas13d causes death of mice

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.