Kaifu Chen

This study shows that RBFOX2 autoregulation is critical for cardiomyocyte differentiation by maturing the transcriptome, and its disruption leads to congenital heart disease.

This study identifies FGFR signaling as a driver of resistance and immune evasion in PIK3CA-driven serous-like endometrial cancer and shows that dual FGFR/PI3K inhibition improves tumor control.

The paper analyzes human endothelial cell heterogeneity across tissues using scRNA-seq data and identifies tissue-specific cell-cell communication patterns.

This study shows that epsin deletion reduces foam cell formation and rewires vascular smooth muscle cell and endothelial functions in atherosclerosis.

MEBOCOST infers metabolite-mediated cell communications from single-cell RNA-seq data, identifying known and novel interactions in mouse brown adipose tissue.

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.

The paper investigates templated insertions at DNA breaks in yeast, showing they are short, inverted duplications formed via a hybrid mechanism involving RPA and Rad27, and are exacerbated in certain mutants.

This study shows that deleting CD45 in endothelial cells reduces atherosclerosis by inhibiting EndoMT and TGFβ signaling through increased FGFR2 and KLF2 expression.

The paper investigates the role of yeast EndoG (Nuc1) in preventing genome instability by degrading cytoplasmic DNA and regulating its transfer to the nucleus.

SCIG identifies cell identity genes using genetic sequence signatures and single-cell RNA-seq data without comparing to other cells, revealing master transcription factors and the role of tissue microenvironment.

This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.

This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.

The paper analyzes intercellular communication in brown adipose tissue using single-cell transcriptomics and identifies temperature-regulated signaling interactions.

The paper introduces MACMIC, a method to identify feature pairs with maximal colocalization and minimal correlation, revealing CTCF's dual role in regulating cell identity genes through epigenetic mechanisms.