Author
University Health NetworkORCID 0000-0001-5013-6123Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Qiang Liu, Milena Gojsevic, Angelica Varesi…·Jean CY Wang
This study shows that PLK1 inhibition eradicates quiescent leukemia stem cells through a non-canonical mechanism involving microtubule and endolysosomal disruption, distinct from its canonical mitotic function.
Angelica Varesi, Sontago Dong, Chiara Gaddoni…·John E. Dick
This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.
Emanuele Lettera, Luca Basso Ricci, Edoardo Carsana…·Raffaella Di Micco
The paper analyzes HSPC aging across the lifespan, finding age-related epigenetic dysregulation and impaired response to proliferative stress, using xenotransplantation models.
Héléna Boutzen, Alex Murison, Alexa Oriecuia…·John Edgar Dick
The paper identifies two distinct leukemia stem cell subtypes with unique transcriptional, epigenetic, and functional properties using a patient-derived cell model and single-cell analysis.