Frédéric Geissmann

The paper reports mutation rates and mutational signatures across 53 normal human cell types, revealing variation in mutation accumulation and identifying known and unknown mutational processes.

The paper identifies a mesodermal progenitor in mouse gastrula and human iPSC cultures that gives rise to pro-definitive angio-hematopoietic lineage cells, including yolk sac endothelium, blood islands, and macrophages.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

The paper identifies clonal inflammatory microglia as a cause of neurodegeneration in LCH and ECD, showing their association with neuronal loss and suggesting CSF1R inhibitors as a therapeutic option.

The paper identifies microglia-specific somatic clones with pathogenic variants in Alzheimer's Disease patients that drive neuro-inflammation through the MAPK pathway.

This study shows that plasma membrane abundance regulates phagocytic capacity and post-phagocytic migration in myeloid cells, with G{beta}4 deficiency leading to increased phagocytosis and altered trafficking.

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

This study identifies two distinct adrenal macrophage subsets in mice and shows that foamy macrophages regulate corticosteroid production through cholesterol accumulation.