Zhaoquan Wang

This study shows that microglial fructose metabolism via GLUT5 is critical for glioblastoma growth, as GLUT5-KO mice live longer with reduced tumor progression.

This study shows that early life high fructose exposure impairs microglia function and neurodevelopment, with GLUT5 deletion reversing these effects.

This paper develops a protocol to efficiently generate tissue-resident macrophages from mouse pluripotent stem cells, enabling in vitro and in vivo modeling of their development.

This study shows that β2 integrins regulate macrophage phagocytosis based on cargo rigidity, acting as a mechanical checkpoint to control engulfment strategies.