Siyuan Hao

This study identifies that the AAV2.5T capsid's VP1u region depends on GPR108 for transduction of human airway epithelium, and that doxorubicin enhances transduction by improving nuclear import.

This study identifies SLC35A1 as a host factor essential for rAAV transduction, showing its role in vector nuclear import across multiple AAV serotypes.

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.