Jianming Qiu

This paper identifies TBC1D23 as a host protein that binds AAVR and mediates endosome-to-TGN trafficking required for rAAV transduction.

This study identifies human transferrin receptor 1 (hTfR) as a co-receptor for parvovirus B19 (B19V) entry into erythroid progenitor cells, showing that hTfR binding to the viral VP1u protein is critical for viral internalization and replication.

This study identifies that the AAV2.5T capsid's VP1u region depends on GPR108 for transduction of human airway epithelium, and that doxorubicin enhances transduction by improving nuclear import.

This study identifies SLC35A1 as a host factor essential for rAAV transduction, showing its role in vector nuclear import across multiple AAV serotypes.

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.