Jelena Misic

This study shows that respirasomes are not essential for maintaining respiratory-chain complexes after their assembly, even under mitochondrial stress or impaired OXPHOS biogenesis.

This study shows that loss of CHCHD2 and CHCHD10 causes tissue-specific bioenergetic defects in cardiac and skeletal muscle, leading to distinct pathological outcomes.

This study identifies a novel link between ATP synthase and the TCA cycle using crosslinking mass spectrometry, showing how ATP synthase interacts with TCA cycle enzymes and adapts under mitochondrial dysfunction.

The paper shows that inhibiting mitochondrial DNA transcription in mice increases fatty acid oxidation, reducing obesity and liver fat while decreasing oxidative phosphorylation capacity.

This study shows that mice with reduced respirasomes maintain normal bioenergetics and physiology, suggesting respirasomes are not essential for basic function but may have other roles.