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This study shows chemokine-induced cell swelling increases plasma membrane fluidity, enhancing CD8+ T cell migration through adhesion-dependent gradients.

The paper identifies immune cell subsets with distinct functional behaviors based on plasma membrane order using biophysical profiling and transcriptome analysis.

This study shows that mild dehydration of biomimetic cell membranes causes reversible anomalous subdiffusion of lipids, indicating a shift in diffusion mode rather than membrane damage.

This study investigates the effects of TMEM30A loss on immune cell membrane dynamics, revealing PS externalization, proteome reorganization, and glycocalyx remodeling with implications for immune therapy.

This study identifies ppGpp-binding proteins in plants and cyanobacteria using chemoproteomics, revealing novel regulatory targets and conserved mechanisms compared to E. coli.

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

This study uses simulations to show that phosphatidylserine induces conformational changes in ADAM10, leading to its activation and reduced antibody binding.

The paper introduces Prodan-based solvatochromic probes for imaging organelle polarity, showing organelle-specific polarity changes under starvation.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

This study shows that estrogen pretreatment of cardiac progenitor cells improves their engraftment and therapeutic efficacy in a failing heart model, enhancing cardiac recovery and reducing pathological remodeling.

This study demonstrates elasto-inertial focusing of sub-25 nm particles in straight microchannels, enabling high-resolution separation of biological nanoparticles for biomedical applications.

The paper revises the diffusion law to quantify nanoscale membrane organization parameters using STED-FCS data, validating the Saffman-Delbruck assumption for lipid diffusion.

The paper introduces iSPP, an imaging-based method for analyzing nanoscale bioparticles using conventional confocal microscopy and provides software for its application.

This study compares lipid-based probes for plasma membrane labeling in live, fixed, and permeabilized cells, identifying a superior probe based on its lipid structure.

VISION is an open-source software for automated multi-dimensional image analysis of cellular biophysics, enabling high throughput and correlative analysis of biophysical properties.

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

This paper develops a TIR-FCS assay to measure membrane fluidity in live bacteria and finds that cold shock reduces membrane fluidity in Bacillus subtilis.

This study uses super resolution microscopy to observe Arc high-order oligomers in excitatory synapses, revealing their role in AMPA receptor dynamics.

This study shows that activating estrogen receptors in male mice reduces HFD-induced liver steatosis by modulating gene expression and TEAD1, suggesting TEAD1 inhibition as a therapeutic strategy for NAFLD.

The paper quantifies how fluorescence lifetime responds to environmental changes in membrane order probes and highlights their sensitivity to biophysical properties.

The paper shows cholesterol inhibits GPCR-mediated phospholipid scrambling in synthetic vesicles, suggesting a mechanism for maintaining plasma membrane asymmetry.

This paper introduces a high-throughput platform for identifying host binding factors and antiviral drug targets by overcoming limitations in host plasma membrane complexity.

This study identifies PCYT2 as critical for muscle health and aging, showing its deficiency causes muscle weakness and aging, and demonstrates therapeutic potential through AAV-based delivery.

This study compares Laurdan and di-4-ANEPPDHQ probes to determine if they measure the same membrane properties, finding they report different lipid packing characteristics.

The paper measures diffusion dynamics of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles using STED-FCS, showing actin cortex influences diffusion modes.