Thomas E. Smithgall

This study shows that HIV-1 Nef homodimerization is critical for kinase activation and that disrupting this interface with small molecules inhibits viral replication and restores immune recognition.

This study shows that a small molecule Pfn1 inhibitor reduces tumor angiogenesis in renal cell carcinoma by targeting endothelial cell Pfn1.

This study identifies PDA1 as an SH3-binding allosteric modulator that stabilizes Hck conformation, potentially enhancing combination therapy with ATP-site inhibitors.

This study develops PROTACs to degrade HIV-1 Nef, restoring CD4 and MHC-I expression and inhibiting HIV-1 replication in T cells and PBMCs.