Michael Way

SPIN90 selectively activates ArpC5L-containing Arp2/3 complexes to make linear actin filaments, shaping lamellipodial filament orientation and protrusion efficiency in B16 melanoma cells.

This study identifies the actomyosin cortex, regulated by Arpc5, as critical for t-tubule remodeling in muscle, linking it to muscle function and disorders.

This study shows that myofibers use Arp2/3-dependent membrane protrusions to drive myoblast fusion and myonuclear accretion during postnatal muscle growth.

This study shows that Arpc5-containing Arp2/3 complexes are critical for macrophage function and maintaining host-microbiota homeostasis, as their loss leads to intestinal inflammation.

This study uses cryo-electron tomography and SIM to analyze vaccinia virus egress, revealing septin and clathrin roles in viral spread and release.

This study identifies distinct roles of TOP2A and TOP2B in vaccinia virus replication, showing TOP2A promotes replication while TOP2B suppresses it by forming antiviral granules.

This study identifies vinorelbine as a compound that enhances the efficacy of a GM-CSF-armed oncolytic vaccinia virus in treating ovarian cancer in mice.

The paper reveals that human SPIN90 forms dimers to nucleate bidirectional actin filaments via Arp2/3, with structural insights showing conserved dimerisation in metazoans.

This study shows CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes, with CK-869 uniquely affecting ArpC1B and Arp3-containing complexes, impacting phagocytosis and migration in macrophages.

The paper shows that Arp2/3 complex can re-nucleate actin branches without NPF activation after debranching, suggesting a self-repair mechanism for actin networks.