Author

Ryan Silk

Institute of Genetics and CancerORCID 0000-0001-6421-1294Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Ryan Silk1 paper · Institute of Genetics and Cancer;

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Ailith EwingiD· 2 shared Alison M. MeynertiD· 2 shared Colin A M SempleiD· 2 shared Graeme R. GrimesiD· 2 shared Agavni MesropianiD· 1 shared Alan W. StittiD· 1 shared Albert Gris‐OliveriD· 1 shared Alhafidz HamdaniD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

Ailith EwingORCID

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3 papers

Recent·Most cited

Cancer BiologyNature GeneticsPeer-reviewedFeb 1, 2026

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

Anagha Krishna, Alison M. Meynert, Karamjit Singh Dolt…·Derya Deniz Ozdemir

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

16 citationstop 1%

humanwhole-genome sequencing

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Cancer BiologyNature CommunicationsPeer-reviewedJul 1, 2025

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

Ailith Ewing, Alison M. Meynert, Ryan Silk…·Colin A M Semple

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

19 citationstop 3%

humanwhole-genome sequencing

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BioinformaticsVision ResearchPeer-reviewedNov 30, 2023

Mapping the daily rhythmic transcriptome in the diabetic retina

Ryan Silk, Hanagh Winter, Ouria Dkhissi‐Benyahya…·Eleni Beli

This study examines how diabetes affects the daily rhythmic gene expression in retinas, finding phase shifts in the transcriptional cycle linked to metabolic and hypoxia pathways.

4 citations

mousebulk RNA-seq

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