Tao Cheng

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.

This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.

This study shows that impaired centrosome biogenesis in kidney stromal progenitors reduces interstitial cell abundance and accelerates fibrosis after injury.

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.