Moe R. Mahjoub

This study identifies three sequential stages of actomyosin remodeling in podocyte injury across multiple kidney diseases, suggesting a structured, potentially reversible response.

This paper develops a deep learning tool for automated segmentation and morphological analysis of lateral ventricles in rodent MRIs, achieving high accuracy and correlation with manual measurements.

The paper identifies cellular defects beyond motility loss in ciliopathies caused by CCDC39/CCDC40 variants, showing proteostasis disruption and cell fate switching.

This study shows IVH reduces ciliated ependymal cells but does not disrupt cilia function or CSF flow networks in the lateral ventricles.

This study uses single-nucleus multi-omics to analyze mouse PKD progression, identifying cell-type-specific gene and epigenetic changes and conserved regulatory pathways between mouse and human.

This study shows DLG1 regulates ciliary protein trafficking in kidney cells, with loss of DLG1 causing ciliary elongation and cysts, and a specific DLG1 variant linked to kidney disease.

This paper describes a U-ExM protocol for analyzing subcellular structures in mouse and human kidney tissues with high detail using conventional microscopy.

This study shows that disrupting centrosome biogenesis in nephron progenitor cells causes kidney developmental defects and fibrocystic disease through reduced cell populations, premature differentiation, and altered signaling pathways.

This study shows that impaired centrosome biogenesis in kidney stromal progenitors reduces interstitial cell abundance and accelerates fibrosis after injury.

This study shows that inhibiting centrosome clustering reduces cyst growth and improves kidney function in ADPKD by activating p53-mediated apoptosis.

The paper uses super-resolution imaging to reveal a novel hybrid cilium in airway multiciliated cells and its role as a signaling center.