Author

Paul A. Randazzo

National Institutes of HealthORCID 0000-0001-5349-0881Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:imaging· 1 Organism:mouse· 1 Approach:simulation· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander J. SodtiD· 2 shared Eric RosenbergiD· 2 shared Olivier SoubiasiD· 2 shared R. Andrew ByrdiD· 2 shared Rebekah A. JacksoniD· 2 shared Xiaoying JianiD· 2 shared Benjamin J. Hu· 1 shared Bih‐Rong Wei· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBiochemistry

Alexander J. SodtORCID

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3 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedSep 30, 2025

The PH domain in the ArfGAP ASAP1 drives catalytic activation through an unprecedented allosteric mechanism

Olivier Soubias, Samuel L. Foley, Xiaoying Jian…·R. Andrew Byrd

The study reveals an allosteric mechanism by which the PH domain of ASAP1 enhances Arf1 GTPase activity through structural and dynamic interactions on a membrane surface.

2 citations

structural biologyexperimental assay

𝕏 PostBluesky

Cancer BiologyCell Reports MethodsPeer-reviewedJul 1, 2024

Fusion-negative rhabdomyosarcoma orthotopic tongue xenografts for study of invasion, intravasation and metastasis in live animals

Sarah Musa Hammoudeh, Yeap Ng, Bih‐Rong Wei…·Paul A. Randazzo

7 citations

mouseimaging

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BiochemistryPLoS ONEPeer-reviewedApr 4, 2024

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

Eric Rosenberg, Xiaoying Jian, Olivier Soubias…·Paul A. Randazzo

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

1 citation

experimental assayprotein folding & dynamics

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