Alexander J. Sodt

The paper investigates how α-synuclein interacts differently with VDAC isoforms by analyzing binding kinetics and translocation behavior in planar lipid membranes.

This paper introduces a method to estimate protein-induced curvature of lipid bilayers using molecular simulations by correlating molecular position with curvature in thermally fluctuating bilayer modes.

This study identifies how different insertion configurations of the fusion peptide in HPIV3 influence membrane curvature during viral fusion.

The paper shows that ether linkages in phospholipids modulate membrane mechanics and topology through distinct physical mechanisms, explaining their evolutionary conservation and biological roles.

This paper investigates the interaction between influenza HA's cytoplasmic tail domain and PIP2 using MD and FPALM, finding electrostatic and hydrophobic contributions to HA-PIP2 binding.

This study investigates the structural role of PRPH2 and Rom1 in photoreceptor outer segment disk curvature using BN-PAGE and MD simulations, revealing their interaction web and curvature mechanisms.

This study reveals that fingolimod, a multiple sclerosis drug, disrupts bacterial membranes through permeabilization, providing insight into its off-target antimicrobial activity.

The paper develops a bilayer continuum model to predict how lipid composition affects protein curvature sensing in membranes.

The study reveals an allosteric mechanism by which the PH domain of ASAP1 enhances Arf1 GTPase activity through structural and dynamic interactions on a membrane surface.

The paper analyzes ergosterol metabolism in yeast to show how successive modifications balance lipid ordering and fluidity for membrane phase separation.

This study shows that variance in curvature sensitivity of lipids affects membrane stiffness, with coarse-grained models showing greater softening due to clustering.

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

The paper reports the first structure of the Mg2+ transporter MgtA using cryo-EM, revealing its dimeric form and mechanism of Mg2+ transport.

This study investigates how Syt-7 C2 domains generate membrane curvature through electrostatic interactions and the wedge mechanism, using simulations and assays.