Author

Nathan C. Denham

University of ManchesterORCID 0000-0001-5413-8070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:electrophysiology· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Alice S. WhitleyiD· 2 shared Andrew W. TraffordiD· 2 shared Charlotte E. R. SmithiD· 2 shared David Charles HutchingsiD· 2 shared George W. P. MaddersiD· 2 shared Katharine M. DibbiD· 2 shared Callum J QuinniD· 1 shared Charles Michael PearmaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersPhysiology

Alice S. WhitleyORCID

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2 papers

Recent·Most cited

PhysiologyJournal of Molecular and Cellular Cardiology PlusPeer-reviewedMay 15, 2026

Acute sildenafil administration reduces susceptibility to induced atrial fibrillation in sheep

George W. P. Madders, Nathan C. Denham, David Charles Hutchings…·Katharine M. Dibb

This study shows that acute sildenafil administration reduces atrial fibrillation susceptibility in sheep by prolonging refractory periods and altering electrophysiological properties.

DOI 10.1016/j.jmccpl.2026.100853

electrophysiologyexperimental assay

𝕏 PostBluesky

PhysiologyJournal of Molecular and Cellular CardiologyPeer-reviewedJan 4, 2026

Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development

Charlotte E. R. Smith, Callum J Quinn, Jessica D. Clarke…·Katharine M. Dibb

This study examines atrial t-tubule development in sheep, showing that despite reduced density in newborns, Ca2+ handling is maintained through increased L-type Ca2+ current and sarcoplasmic reticulum content.

2 citationstop 5%

electrophysiologyexperimental assay

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