Author

Chakrapani Subramanyam

Pfizer (United States)ORCID 0000-0001-5451-0450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Aiping DongiD· 2 shared Aliakbar Khalili Yazdi· 2 shared C.H. ArrowsmithiD· 2 shared Dafydd R. OweniD· 2 shared Dalia Baršytė-LovejoyiD· 2 shared Dong ChengiD· 2 shared Feng Wang· 2 shared Jinrong MiniD· 2 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Aiping DongORCID

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2 papers

Recent·Most cited

Molecular BiologyNature Chemical BiologyPeer-reviewedMay 21, 2024

A chemical probe to modulate human GID4 Pro/N-degron interactions

Dominic D. G. Owens, Matthew E. R. Maitland, Aliakbar Khalili Yazdi…·C.H. Arrowsmith

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

41 citationstop 3%

humanproteomics

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BiophysicsRSC Medicinal ChemistryPeer-reviewedJan 1, 2024

Chemical Tools for the Gid4 Subunit of the Human E3 Ligase C-terminal to LisH (CTLH) Degradation Complex

Aliakbar Khalili Yazdi, Sumera Perveen, Dong Cheng…·Dafydd R. Owen

The paper develops chemical tools and probes for the Gid4 subunit of the human CTLH E3 ligase complex, achieving sub-100 nM binding affinity for further study.

18 citations

humanexperimental assay

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